the Potential Antiepileptic Activity of Spirulina: The Concept of Antioxident Properties in Rats Model of epilepsy

Abstract

Spirulina platensis (blue-green algae) is a nutritional supplement. It constitutes of high content of protein, antioxidants, various phytopigments and possesses neuroprotective activities. Epilepsy  is recognized as a neuropsychiatric disorder in humans with a reduced lifespan followed with impairments in social as well as vocational functioning.. penzyltetrazole  recognized as one of the best drugs to that  can develop an animal model of the disorder. Various antiepileptic  are considered as approved treatment therapy for the symptoms of epilepsy  but they also exert adverse effects. Thus, there is an excessive need for novel treatment(s) with negligible adverse effects. Present study was designed to evaluate the neuroprotective effects and antioxidant effect  of spirulina in PTZ  rat model of epilepsy. Spirulina was tested at the dose of 200 mg/kg. Results showed that administration of spirulina improved behavioral deficits and combated the oxidative damage evident by a significant reduction in lipid peroxidation and increase in antioxidant level. Thus, from present findings it may be suggested that spirulina can be used as a therapy for preventive or therapeutic measures.

Method and material

The selected rats were divided randomly into 5 groups with 5 rats in each group as following:

Group 1 is Control group  Group 2: Rats received i.p. PTZ 40 mg/kg each 48 hrs .

Group 3: Rats received 400 mg/kg  sodium valproate  orally and PTZ 40 mg / kg.

Group 4: Rats received spirulina 200 mg/kg  orally and  40 mg/kg PTZ.

Group 5: Rats received sodium vaporte  mg/kg and spirulina and  PTZ 40 mg/kg.

Then the Interlukin-6 (IL-6), tumor necrosis factor TNF  were estimated using brain tissue homogenate.

Results

Administration of spirulina alone and as combination with antiepileptic drug show decrease in oxidative stress biomarkers MDA that induced by PTZ induction .

Conclusions

from present findings it may be suggested that spirulina can be used as a therapy for preventive or therapeutic measures for epilepsy as it show strong antioxidant effect induced By PTZ in rat seizure model .